How to Live Beyond Age 120

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By The Eismans (And we should know as we are doctors)

PART ONE

INTRODUCTION

This little document outlines the changes that you must make in your life that will allow longevity. Because some of our readers may have problems with long documents, we have divided the subject into small, easy to digest chunks.

The most important factor is genes, and that nasty little problem will be addressed in the first chapter. After all, turtles commonly live beyond the age of 150 years. There is even a deep ocean shark that lives longer than 500 years. I’m jealous, why can’t we live for five centuries? Of course, 500 years can get boring. Do these sharks meet for Mahjong on Tuesdays and a book club on Thursdays?

The following chapters will address changes in diet, exercise, and of course vitamins and supplements. How many gallons of coffee are we allowed each day. We will also discuss genetics which we are on the cusp of being able to control in our brave new world. How many of my readers know what Crispr is? I bet you have nightmares.

Our sincerest thanks to our editor, Elyktra Eisman who helped arrange these topics in a well organized English. We also must thank Google which we freely plagiarized. Near the end of this document is a bibliography for those who want to pursue this subject further, or those who are a doubtful Thomas and want to see the data with their own eyes.

GENES

Your family history is the biggest factor that controls your longevity. Nature has assigned each species a life expectancy based on their genetic makeup. Humans have been extensively studied. For some reason, we seem to have a particular interest in human genetics.

So what is this clock that controls our time on earth? One factor is the length of our telomeres. We have a copy of our plans, much like the plans used in the construction of your home in every cell in our body. These plans, made up of deoxyribonucleic acid, are detailed instructions on every aspect of your structure, including how you are built, chemical make-up etc. Even the color of your hair and eyes are outlined somewhere in the DNA (I can’t keep typing deoxyribonucleic acid). The surprising fact is that DNA is made up of only four chemical bases. These four segments of your DNA, are arranged in different patterns and represent the words that hold the code for the meaning of life.1 James Watson and Francis Crick, after discovering DNA, stormed into a bar near the university exclaiming, “We have discovered the meaning of life.” Imagine if you had a language that consisted of only 4 letters, ie A,B,C, and D (essentially the four bases that make up DNA). Every word in your language was only a combination of those four letters. This is the language, or code of DNA. A copy of this DNA is in every cell of your body. The cell is smart enough to utilize only that part of the DNA strand that is of important to its structure.

So where does this thing, “telomere” come in? It is like the blank tape that begins and ends the film in a movie theater. You know the part of the film that is fed into the projector at the start of the picture, and the end of the film that is still in the projector reel at the end. A telomere is made up of a jumble of the four letters that is meaningless.

There is no information in this telomere – unlike the rest of the DNA strand which has our complete building instructions. It is as if every room in your house had had the blueprint of the entire house framed on the wall. While each cell duplicates through our entire life, the DNA also goes through a replicator system. As the DNA strand is fed through the replicator, the beginning and end of the strand gets clipped off. That’s okay, after all, there is no information on the telomere that we need anyway.

Ah, but here is the problem. With each replication of the DNA, the telomere gets shortened until we begin to lose the beginning and end of our DNA. The telomere is merely the leader, and is made up of meaningless strings of these four bases. When the telomere is finished, and you start losing the meaningful code in DNA, you are finished. Without the information in the complete DNA strip, we begin to die. How can you build a copy of a house without a complete set of plans?

So what is the solution? After all, this is one of the main reasons why some people get diabetes, heart attacks, strokes, early in life. Obviously choosing your parents is critical here. If your Mother and Father died after the age of 100, you are in luck. Now, I have had patients divorce their parents, and get adopted by mothers and fathers with good histories, but it does not seem to work very well to solve the problem.

Well, not so fast. The future is here. We now have Crispr. For those who do not know what Crispr is (and it is not a misspelling), it is a machine that allows us to cut and rebuild DNA. Someday, you will visit your physician, and he will tell you that you have a defective gene that puts you at risk of having diabetes, or (heaven forbid) Huntington’s Chorea. Step into this machine, and we will correct this defective part of your DNA. In the future we will be able to send reels of our DNA to Paramount or MGM, so that their lab can add a few miles of leader to each reel, and thereby eliminate aging and extend life. Are you shaking in fear? Already, a scientist in China has used Crispr to build an infant. He went into hiding, but the Chinese government found him and he was sentenced to prison for three years. If you don’t believe me, check our bibliography for an article that documents a study where the Chinese scientist, Jiankui created twin girls with his Crispr.2 Not everyone is looking forward to our brave new world. The Chinese have become masters of gene editing, and so we will leave this subject, and go on to factors that we can change at the present time.

Dr. Eisman is the author of Bitter Medicine. To purchase a copy, click HERE.

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